The most common type of aquaporin in the brain is aquaporin 4 (AQP4), which plays a significant role in the blood-brain barrier (BBB) and brain-cerebrospinal fluid border, as well as regulates the movement of water in the brain. The blood-brain barrier separates blood from the brain, which involves the mix of firmly connected endothelial cells.
Aquaporins (AQPs) or water channels are a family of integral membrane proteins that form hydrophilic pores in the cellular membrane. They are involved in the water transport through the membrane. All cells depend on their ability to maintain water homeostasis. This is achieved through the action of aquaporins, membrane-bound water channels that facilitate water flow across cellular membrane.